This content is only available for ASCRS Members
This content from the 2020 ASCRS Virtual Annual Meeting is only available to ASCRS members. To log in, click the teal "Login" button in the upper right-hand corner of this page.
Filed Under
Cataract
medication
inflammation
intracameral antibiotic
post-operative
endophthalmitis
2020 paper presentation
Purpose
To better understand why studies of topical and oral supplemental administration of antibiotics have not conclusively shown efficacy in preventing post-operative endophthalmitis, and when they may be effective
Methods
Mathematical models of intracameral antibiotic concentration decay in the anterior chamber compared to resistance levels were created to better understand the duration of antibacterial efficacy of intracameral administration of prophylactic antibiotics. The additional anterior chamber concentration effects of topical and oral supplementation were determined and plotted.
Results
Graphs of antibiotic concentration decay were drawn illustrating what happens under various assumptions. The results are consistent with experimental data from the literature.
Conclusion
The study of models of intracameral antibiotic concentration decay can enhance our understanding of the effects of our current protocols and suggest better practices.
To better understand why studies of topical and oral supplemental administration of antibiotics have not conclusively shown efficacy in preventing post-operative endophthalmitis, and when they may be effective
Methods
Mathematical models of intracameral antibiotic concentration decay in the anterior chamber compared to resistance levels were created to better understand the duration of antibacterial efficacy of intracameral administration of prophylactic antibiotics. The additional anterior chamber concentration effects of topical and oral supplementation were determined and plotted.
Results
Graphs of antibiotic concentration decay were drawn illustrating what happens under various assumptions. The results are consistent with experimental data from the literature.
Conclusion
The study of models of intracameral antibiotic concentration decay can enhance our understanding of the effects of our current protocols and suggest better practices.
View More Presentations from this Session
This presentation is from the session "SPS-111 Cataract Surgery - Medications" from the 2020 ASCRS Virtual Annual Meeting held on May 16-17, 2020.